Overview
Andarine (S-4) was the first SARM brought to the mainstream and remains a favourite for pre-contest cutting and hardening. It binds androgen receptors in muscle and bone with moderate affinity, producing a dry, vascular look reminiscent of low-dose Winstrol but without the joint discomfort.
Why Athletes Use S-4
- Vascularity & Definition: Enhances muscle separation and vein prominence in weeks.
- Strength Maintenance: Preserves lifts deep into a caloric deficit, ideal for photoshoot prep.
- Fat Loss Synergy: Slightly raises metabolic rate and may up-regulate lipolytic genes.
Unique Side-Effect – “Yellow Vision”
Andarine metabolites bind to ocular receptors causing a temporary yellow tint and difficulty adjusting to darkness. Symptoms appear at >50 mg and disappear within days of cessation. Split dosing (AM/PM) mitigates severity.
Usage Guidelines
| Goal | Dose | Length | Notes |
|---|---|---|---|
| Cutting | 25 mg BID (50 mg) | 6-8 wk | Evaluate vision weekly. |
| Recomp | 12.5 mg BID | 8 wk | Stack with Testosterone base. |
Side-Effects & Mitigation
- Suppression: Moderate; mini-PCT (e.g. 20/20/10/10 Tamoxifen) advised.
- Liver: Non-hepatotoxic; mild enzyme bump possible at higher doses.
- Lipids: HDL drop similar to Ostarine—fish oil recommended.
Bottom Line: Andarine is a practical bridge between steroids and SARMs for athletes seeking enhanced vascularity and muscle hardness without resorting to harsher DHT derivatives.